In 2019,Organic Letters included an article by Huang, Rong; Li, Zhihong; Yu, Jianghui; Chen, Hongli; Jiang, Biao. Synthetic Route of C6H13NO. The article was titled ãH2O-Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reactionsã? The information in the text is summarized as follows:
A H2O-regulated chemoselective addition in oxa- and aza-Michael reactions for aminoalcs. and mixtures of structurally similar alcs. and amines was reported. The oxa-Michael reactions might be kinetically controlled, and the reactions to produce O-selective products were slowed by the addition of water. The electrophilicity of Michael acceptors and the steric hindrance of Michael donors also affect the ratios of O/N products. This method offers novel ideas over conventional metal-catalyzed or ligand-induced strategies. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Synthetic Route of C6H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts