Category: alcohols-buliding-blocksOn October 16, 2003 ,ãSynthesis of New Chiral Monodentate Phosphite Ligands and Their Use in Catalytic Asymmetric Hydrogenationã?was published in Organic Letters. The article was written by Hua, Zihao; Vassar, Victor C.; Ojima, Iwao. The article contains the following contents:
New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh(I)-catalyzed hydrogenation of di-Me itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability. Ligands thus prepared included (+)-(11aS)-4,8-bis(1,1-dimethylethyl)-1,2,10,11-tetramethyl-6-phenoxydibenzo[d,f][1,3,2]dioxaphosphepin, (11aS)-1,2,10,11-tetramethyl-6-phenoxydibenzo[d,f][1,3,2]dioxaphosphepin, (+)-(11aS)-4,8-bis(1,1-dimethylethyl)-1,2,10,11-tetramethyl-6-[(2-naphthalenyl)oxy]dibenzo[d,f][1,3,2]dioxaphosphepin, (+)-(11aS)-4,8-bis(1,1-dimethylethyl)-1,2,10,11-tetramethyl-6-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]dibenzo[d,f][1,3,2]dioxaphosphepin, etc. The results came from multiple reactions, including the reaction of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Category: alcohols-buliding-blocks)
(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts