The author of ãSynthesis of N-Fused Polycyclic Indoles via Ligand-Free Palladium-Catalyzed Annulation/Acyl Migration Reactionã?were Dong, Zhan; Zhang, Xiao-Wen; Li, Weishuang; Li, Zi-Meng; Wang, Wen-Yan; Zhang, Yan; Liu, Wei; Liu, Wen-Bo. And the article was published in Organic Letters in 2019. COA of Formula: C6H13NO The author mentioned the following in the article:
An efficient synthesis of N-fused polycyclic indoles I (R1 = Me, Bn, etc.; R2 = 2-Me, 3-Me, 2-F, etc.) by a palladium-catalyzed annulation/acyl migration cascade reaction is described. The reaction is ligand-free, scalable, and provides access to a diverse range of useful indole scaffolds from readily available starting materials. Supporting mechanistic studies indicate that the reaction likely proceeds via an intramol. α-arylation mechanism. The synthetic utility of this protocol is demonstrated by a gram-scale reaction and syntheses toward indole alkaloids and a HSP90 inhibitor. In addition to this study using trans-4-Aminocyclohexanol, there are many other studies that have used trans-4-Aminocyclohexanol(cas: 27489-62-9COA of Formula: C6H13NO) was used in this study.
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C6H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts