Safety of 4-Aminobutan-1-olIn 2020 ,ãBig Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymerã?was published in ACS Nano. The article was written by Blakney, Anna K.; Zhu, Yunqing; McKay, Paul F.; Bouton, Clement R.; Yeow, Jonathan; Tang, Jiaqing; Hu, Kai; Samnuan, Karnyart; Grigsby, Christopher L.; Shattock, Robin J.; Stevens, Molly M.. The article contains the following contents:
Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA, thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA and do not necessarily deliver saRNA efficiently due to structural differences of these RNAs, thus motivating the development of saRNA delivery platforms. Here, we engineer a bioreducible, linear, cationic polymer called “”pABOL”” for saRNA delivery and show that increasing its mol. weight enhances delivery both in vitro and in vivo. We demonstrate that pABOL enhances protein expression and cellular uptake via both i.m. and intradermal injection compared to com. available polymers in vivo and that i.m. injection confers complete protection against influenza challenge. Due to the scalability of polymer synthesis and ease of formulation preparation, we anticipate that this polymer is highly clin. translatable as a delivery vehicle for saRNA for both vaccines and therapeutics. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Safety of 4-Aminobutan-1-ol
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