ãFocus on chemistry of the 10-Dioxane-nido-7,8-dicarba-undecahydrido undecaborate Zwitterion; exceptionally easy abstraction of hydrogen bridge and double-action pathways observed in ring cleavage reactions with OH- as Nucleophileã?was published in Molecules in 2020. These research results belong to Bakardjiev, Mario; El Anwar, Suzan; Bavol, Dmytro; Ruzickova, Zdenka; Gruner, Bohumir. Electric Literature of C3H9NO2 The article mentions the following:
Ring cleavage of cyclic ether substituents attached to a boron cage via an oxonium oxygen atom are amongst the most versatile methods for conjoining boron closo-cages with organic functional groups. Here we focus on much less tackled chem. of the 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11], which is the only known representative of cyclic ether substitution at nido-cages, and explore the scope for the use of this zwitterion 1 in reactions with various types of nucleophiles including bifunctional ones. Most of the nitrogen, oxygen, halogen, and sulfur nucleophiles studied react via nucleophilic substitution at the C1 atom of the dioxane ring, followed by its cleavage that produces six atom chain between the cage and the resp. organic moiety. We also report the differences in reactivity of this nido-cage system with the simplest oxygen nucleophile, i.e., OH-. With 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11], reaction proceeds in two possible directions, either via typical ring cleavage, or by replacement of the whole dioxane ring with -OH at higher temperatures Furthermore, an easy deprotonation of the hydrogen bridge in 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11] was observed that proceeds even in diluted aqueous KOH. We believe this knowledge can be further applied in the design of functional mols., materials, and drugs. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C3H9NO2
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