In 2018,MedChemComm included an article by Panczyk, Katarzyna; Zelaszczyk, Dorota; Koczurkiewicz, Paulina; Sloczynska, Karolina; Pekala, Elzbieta; Zeslawska, Ewa; Nitek, Wojciech; Zmudzki, Pawel; Marona, Henryk; Waszkielewicz, Anna. Formula: C6H13NO. The article was titled ãSynthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acidsã? The information in the text is summarized as follows:
A series of new phenoxyacetamides were prepared via multistep chem. synthesis as a continuation of the research carried out on di- and tri-substituted phenoxyalkyl and phenoxyacetyl derivatives of amines. The obtained compounds varied in an amide component, for example aminoalkanol or (un)modified amino acid moieties were introduced. The structures of selected products were confirmed by means of crystallog. methods. All compounds were the subject of preliminary screening for potential anticonvulsant activity (MES, 6 Hz and/or scMET tests) and neurotoxicity (rotarod) in mice after i.p. administration, while several active compounds were subsequently examined in addnl. models (e.g. MES and rotarod – rats, p.o. or i.p., hippocampal kindling – rats, i.p.). Finally, safety studies (cytotoxicity and cell proliferation assays on astrocytes, metabolic stability assessment, mutagenicity evaluation) were performed for several active compounds, including the most promising one (R-(-)-2-(2,6-dimethylphenoxy)-N-(1-hydroxypropan-2-yl)acetamide, MES ED50 = 12.00 mg per kg b.w., rats, p.o.). The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Formula: C6H13NO)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C6H13NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts