Mudasani, Gopal; Paidikondala, Kalyani; Gundla, Rambabu; Joseph Maddirala, Shambabu; Das, Viswanath published their research in ChemistrySelect in 2021. The article was titled 《Synthesis and Biological Evaluation of 5′-Arylspiro[piperidine-4,3′-pyrrolo-[2,3-b]pyridin] Analogues》.Related Products of 7748-36-9 The article contains the following contents:
The synthesis of a novel series of spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one analogs I [R = H, CONH2; Ar = pyrimidin-5-yl, 4-fluorophenyl, 1,3-benzodioxol-5-yl, etc.] and in-vitro antiproliferative activity of these compounds against four human cancer cell lines were reported. Synthesis of analogs I were done using a rational designing approach in a seven-step sequence and the characterization of compounds was performed using 1H-NMR, LC-MS, and 13C-NMR. Thirteen novel compounds I were synthesized in moderate to good yields. The anti-proliferation activity of the compounds I against human breast MCF-7 and MDA-MB-231, leukemic K-562 and lung A549 cancer cells were determined by a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Two compounds among all the synthesized compounds I had moderate IC50 values in MCF-7 cells and thus were identified to have better antiproliferative activity against estrogen-receptor-pos. cancer cells. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9
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