In 2017,Han, Zhengxu S.; Wu, Hao; Xu, Yibo; Zhang, Yongda; Qu, Bo; Li, Zhibin; Caldwell, Donald R.; Fandrick, Keith R.; Zhang, Li; Roschangar, Frank; Song, Jinhua J.; Senanayake, Chris H. published 《General and stereoselective method for the synthesis of sterically congested and structurally diverse P-stereogenic secondary phosphine oxides》.Organic Letters published the findings.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:
Reaction of dichlorophosphines RPCl2 (R = aryl, hetaryl, ferrocenyl, aralkyl) with chiral N-sulfonyl-β-aminoalc. auxiliaries R*OH produced phosphinate esters RPH(O)(OR*), which were then alkylated with tBuLi yielding phosphorus-chiral secondary phosphine oxides RPH(O)(tBu) (3a-k) with >97% ee. A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alc. templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol
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