Category: alcohols-buliding-blocksIn 2022 ,《C(sp3)-H oxygenation via alkoxypalladium(II) species: an update for the mechanism》 was published in Chemical Science. The article was written by Zhang, Shuaizhong; Zhang, Jinquan; Zou, Hongbin. The article contains the following contents:
In the present study of γ-C(sp3)-H acyloxylation of amine derivatives, a different mechanism was shown when tert-Bu hydroperoxide (TBHP) was used as an oxidant-namely, a bimetallic oxidative addition-oxo-insertion process. This catalytic model results in an alkoxypalladium(II) intermediate from which acyloxylation and alkoxylation products was formed. Exptl. and computational studies, including isolation of the putative post-oxo-insertion alkoxypalladium(II) intermediates, support this mechanistic model. D. functional theory revealed that the classical alkylpalladium(IV) oxidative addition pathway was higher in energy than the bimetallic oxo-insertion pathway. Further kinetic studies revealed second-order dependence on [Pd] and first-order on [TBHP], which was consistent with DFT anal. This procedure was compatible with a wide range of acids and alcs. for γ-C(sp3)-H oxygenation. Preliminary functional group transformations of the products underscore the great potential of this protocol for structural manipulation. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts