《Synthesis, α-glycosidase inhibitory potential and molecular docking study of benzimidazole derivatives》 was published in Bioorganic Chemistry in 2020. These research results belong to Taha, Muhammad; Rahim, Fazal; Zaman, Khalid; Selvaraj, Manikandan; Uddin, Nizam; Farooq, Rai Khalid; Nawaz, Muhammad; Sajid, Muhammad; Nawaz, Faisal; Ibrahim, Mohamad; Khan, Khalid Mohammed. Reference of 3,5-Dihydroxybenzaldehyde The article mentions the following:
A series of twenty-six analogs of benzimidazole based oxadiazole I [R = 4-HOC6H4, 2-thienyl, 3-pyridyl, etc.] was synthesized and evaluated against alpha-glycosidase enzyme. Compounds I [R = 2,3-(OH)2C6H3, 2,5-(OH)2C6H3, 3,4-(OH)2C6H3, 4-FC6H4] with IC50 values 4.6 ± 0.1, 9.50 ± 0.3, 2.6 ± 0.1 and 9.30 ± 0.4μM resp. showed excellent inhibitory potential than reference drug acarbose (IC50 = 38.45 ± 0.80μM). Some of the analogs like I [R = 3-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 3,4-(OMe)2C6H4] with Me and methoxy substituent on Ph ring showed hydrophobic interaction and were found with no inhibitory potential. The binding interactions between synthesized analogs I and ligands protein were confirmed through mol. docking study. These derivatives were synthesized by simple mode of synthesis like heterocyclic ring formation. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Reference of 3,5-Dihydroxybenzaldehyde)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Reference of 3,5-Dihydroxybenzaldehyde
Referemce:
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Alcohols – Chemistry LibreTexts