Electric Literature of C7H6O3In 2020 ,《Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents》 was published in Bioorganic Chemistry. The article was written by Taha, Muhammad; Sain, Amyra Amat; Ali, Muhammad; Anouar, El Hassane; Rahim, Fazal; Ismail, Nor Hadiani; Adenan, Mohd Ilham; Imran, Syahrul; Al-Harrasi, Ahmed; Nawaz, Fasial; Iqbal, Naveed; Khan, Khalid Mohammed. The article contains the following contents:
Leishmaniasis has affected a wider part of population around the globe. Most often, the existing regiments to battle against leishmaniasis are inadequate and limited. In our ongoing efforts to develop new leishmanicidal agents, we have synthesized a series of novel and sym. bis-Schiff base-disulfide hybrids 1-27. Intermediate disulfide was synthesized from corresponding 2-aminothiol followed by reacting the coupled adduct with various aromatic aldehydes. All these compounds showed outstanding inhibition when compared with standard (Table 1). Out of twenty seven analogs, twenty two analogs i.e. 1-5, 7-13, 17-21, 23-27 analogs showed excellent inhibitory potential with EC50 values ranging from 0.010 ± 0.00 to 0.096 ± 0.01μM while five compounds i.e. 6, 14-16, and 22 showed good inhibitory potential with EC50 values ranging from 0.10 ± 0.00 to 0.137 ± 0.01μM when compared with the standard Amphotericin B. Structure-activity relationship has been established while mol. docking studies were performed to pin the binding interaction of active mols. This study will help to develop new antileishmanial lead compounds In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Electric Literature of C7H6O3
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