Smolobochkin, Andrey V.; Turmanov, Rakhymzhan A.; Gazizov, Almir S.; Voloshina, Alexandra D.; Voronina, Julia K.; Sapunova, Anastasiia S.; Burilov, Alexander R.; Pudovik, Michail A. published their research in Tetrahedron on August 14 ,2020. The article was titled 《One-pot imination / Arbuzov reaction of 4-aminobutanal derivatives: Synthesis of 2-phosphorylpyrrolidines and evaluation of anticancer activity》.Recommanded Product: 6346-09-4 The article contains the following contents:
A novel one-pot method for the preparation of N-substituted 2-phopshorylpyrrolidines, e.g. I, from readily available 4,4-diethoxybutan-1-amine derivatives and P (III) acid chlorides is described. The presented method benefits from simple reaction and work-up procedures, mild reaction conditions, avoids protecting group introduction-removal stages and provides a straightforward access to target compounds In vitro cytotoxicity studies indicate that obtained 2-phopshorylpyrrolidines inhibit selectively M-Hela tumor cells growth. The activity of some derivatives towards M-Hela and MCF-7 tumor cells is comparable to that of reference drug Tamoxifen. In contrast to Tamoxifen and Doxorubicin tested compounds have no cytotoxic effects on normal cells. After reading the article, we found that the author used 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Recommanded Product: 6346-09-4)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 6346-09-4
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