Ritmaleni; Hastutitama, A. N. A.; Persitamaia, I.; Restiwardani, T.; Eksakta, A.; Munandar, R. F.; Abdullah, M. S.; Purwanto, A. E.; Astuti, P.; Sardjiman published their research in Rasayan Journal of Chemistry in 2021. The article was titled 《Synthesis and antibacterial activity of dibenzylidene-cyclohexanone》.Safety of 3-Hydroxybenzaldehyde The article contains the following contents:
Dibenzylidene-cyclohexanones I (R = 3-O2NC6H4, 2-CH3OC6H4, 4-OH-3-CH3OC6H3, etc.) were synthesized by reacting aromatic aldehydes RCHO with cyclohexanone in the acidic condition through the carbonyl condensation reaction. The antibacterial activity was tested by using microdilution method against K. pneumonia, E. coli, S. aureus, B. subtilis and E. faecalis. The isolated products were obtained as pure curcumin analogs with moderate to high yield. The antibacterial assay showed that I (R = 3-OHC6H4) gave MIC and MBC at 50μg/mL in E. coli, S. aureus, and E. faecalis. Moreover, it showed that the percentage inhibition of B. subtilis was around 54% at a concentration of 25μg/mL. Among all the tested compounds, I (R = 3-OHC6H4) showed better activity against all those bacteria while none showed activity against K. pneumonia. A I (R = 2,5-CH3OC6H3) was obtained as the compound with the highest yield and I (R = 3-OHC6H4) was the most potent compound While I (R = 2-OH-3-C2H5OC6H3) was the most potent compound according to the docking study. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde
Referemce:
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Alcohols – Chemistry LibreTexts