In 2019,Tetrahedron Letters included an article by Qiu, Zhenjiang; Zhu, Mingxiang; Zheng, Lu; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng. HPLC of Formula: 18621-18-6. The article was titled 《Regioselective α-benzylation of 3-iodoazetidines via Suzuki cross-coupling》. The information in the text is summarized as follows:
An efficient protocol for the synthesis of α-benzyl azetidines I [R = 4-F3COC6H4, 2-F-C6H4, naphthalen-2-yl, etc.; R1 = C(O)OCH2C6H5, C(O)OC(CH3)3] starting from benzylboronic acid pinacol ester derivatives II and 3-iodoazetidine III was developed. A wide range of α-benzyl azetidine derivatives I was obtained in moderate to good yields with high regioselectivity (>99%). In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6HPLC of Formula: 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.HPLC of Formula: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
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Alcohols – Chemistry LibreTexts