Piccini, Ilaria; Sousa, Marta; Altendorf, Sabrina; Jimenez, Francisco; Rossi, Alfredo; Funk, Wolfgang; Biro, Tamas; Paus, Ralf; Seibel, Jens; Jakobs, Mira; Yesilkaya, Tanju; Edelkamp, Janin; Bertolini, Marta published an article in 2022, the title of the article was Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype.Formula: C3H6O4 And the article contains the following content:
Female pattern hair loss (FPHL) is a non-scarring alopecia resulting from the progressive conversion of the terminal (t) scalp hair follicles (HFs) into intermediate/miniaturized (i/m) HFs. Although data supporting nutrient deficiency in FPHL HFs are lacking, therapeutic strategies are often associated with nutritional supplementation. Here, we show by metabolic anal. that selected nutrients important for hair growth such as essential amino acids and vitamins are indeed decreased in affected iHFs compared to tHFs in FPHL scalp skin, confirming nutrient insufficiency. IHFs also displayed a more quiescent metabolic phenotype, as indicated by altered metabolite abundance in freshly collected HFs and release/consumption during organ culture of products/substrates of TCA cycle, aerobic glycolysis, and glutaminolysis. Yet, as assessed by exogenous nutrient supplementation ex vivo, nutrient uptake mechanisms are not impaired in affected FPHL iHFs. Moreover, blood vessel d. is not diminished in iHFs vs. tHFs, despite differences in tHFs from different FPHL scalp locations or vs. healthy scalp or changes in the expression of angiogenesis-associated growth factors. Thus, our data reveal that affected iHFs in FPHL display a relative nutrient insufficiency and dormant metabolism, but are still capable of absorbing nutrients, supporting the potential of nutritional supplementation as an adjunct therapy for FPHL. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Formula: C3H6O4
The Article related to hair follicle human nutrient insufficiency dormant metabolism, female pattern hair loss, hair follicle, metabolism, nutrient supplementation, Animal Nutrition: Other and other aspects.Formula: C3H6O4
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