《Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides》 was published in Chemical Science in 2020. These research results belong to Pagire, Santosh K.; Kumagai, Naoya; Shibasaki, Masakatsu. Recommanded Product: 7748-36-9 The article mentions the following:
A cooperative catalytic system comprising a chiral Cu(I) complex and an Ir(III) photocatalyst fueled by visible-light irradiation that allows for seamless integration of the catalytic formation of a-amino alkyl radicals and subsequent enantioselective addition to α,β-unsaturated amides I [R = H, OMe; R1 = Me, Ph, pyridin-2-yl, etc.; R2 = H, Me; R3 = H, OMe, Cl; X = CH2, C(CH3)2] was reported. A 7-aza-6-MeO-indoline attachment on the amide substrates plays a pivotal role in suppressing the undesired pathways, resulting in excellent enantioselectivity and enabling expedited access to valuable γ-aminobutyramides II (R4 = Ph, 2-fluorophenyl; R5 = H, Me, i-Pr, Bn). The indoline amide was readily diversified with full recovery of the azaindoline attachment, highlighting the synthetic utility of this cooperative catalytic system. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9
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