In 2018,Mogharabi-Manzari, Mehdi; Amini, Mohsen; Abdollahi, Mohammad; Khoobi, Mehdi; Bagherzadeh, Ghodsieh; Faramarzi, Mohammad Ali published 《Co-immobilization of Laccase and TEMPO in the Compartments of Mesoporous Silica for a Green and One-Pot Cascade Synthesis of Coumarins by Knoevenagel Condensation》.ChemCatChem published the findings.HPLC of Formula: 26153-38-8 The information in the text is summarized as follows:
Co-immobilization of bio- and chemocatalysts produces sustainable, recyclable hybrid systems that open new horizons for green cascade approaches in organic synthesis. Here, the co-immobilization of laccase and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) in mesoporous silica was used for the one-pot aqueous synthesis of 30 coumarin-3-carboxylate derivatives under mild conditions through the condensation of in situ oxidized 2-hydroxybenzyl alcs. and malonate derivatives A maximum yield was obtained after incubating at pH 6.0 and 45°C for 24 h. An efficient organic synthesis was catalyzed by the hybrid catalyst in 10% organic solvent. More than 95% of the initial activity of the enzyme was preserved after 10 cycles, and no significant catalyst deactivation occurred after 10 runs. This new system efficiently catalyzed the in situ aerobic oxidation of salicyl alcs., followed by Knoevenagel condensation, which confirmed the possibility of producing efficient hybrid catalysts by co-immobilization of catalytic species in mesoporous materials. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts