On January 10, 2013, Liu, Xingjin; Zhang, Xuke published a patent.Safety of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives for treating bacteria and protozoan infection. And the patent contained the following:
The title C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives I [wherein wherein R1 = H, OH, or OMe; R2 = OH; R3 = organic substituent with optional heteroatom(s); R4 = H, Cbz, Bz, or Ac] or pharmaceutically acceptable salts thereof were prepared for treating bacteria and protozoan infections. For example, II was prepared in a multi-step synthesis. Some title compounds showed antibacterial activity with MIC of 0.125 pg/mL, which is 32 times better than Azithromycin and Clarithromycin. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Safety of (2-Fluorophenyl)methanethiol
The Article related to preparation erythromycin a antibacterial agent human, Carbohydrates: Amines and other aspects.Safety of (2-Fluorophenyl)methanethiol
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