Category: alcohols-buliding-blocksIn 2022 ,《Advances in Stereoselective Iron(II)-Catalyzed Synthesis of Sulfilimines with N-Mesyloxycarbamates》 was published in Helvetica Chimica Acta. The article was written by Lai, Calvine; Lebel, Helene. The article contains the following contents:
A stereoselective amination of thioethers R1SR2 to access sulfilimines (R)-R1R2SNC(O)OR3 [R1 = Ph, naphthalen-2-yl, thiophen-2-yl, etc., R2 = Me, Et, R3 = (4-methylphenyl)methyl, diphenylmethyl, 2,2,2-trichloroethyl, etc.] using N-mesyloxycarbamates MsOHNC(O)OR3 in a catalytic system composed of iron(II) chloride and a pyridine oxazoline (PyOX) ligand, e.g., (S)-5,5-dimethyl-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole, has been developed. The reaction proceeds with modest to good yields and selectivities (up to 86:14 d.r. and 72:28 e.r.). Selectivity was controlled by both the structure of the chiral ligand and the amination reagent. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Category: alcohols-buliding-blocks)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts