The author of 《Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo》 were Kozielski, Kristen L.; Ruiz-Valls, Alejandro; Tzeng, Stephany Y.; Guerrero-Cazares, Hugo; Rui, Yuan; Li, Yuxin; Vaughan, Hannah J.; Gionet-Gonzales, Marissa; Vantucci, Casey; Kim, Jayoung; Schiapparelli, Paula; Al-Kharboosh, Rawan; Quinones-Hinojosa, Alfredo; Green, Jordan J.. And the article was published in Biomaterials in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:
Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA mols. into a single nanoparticle, facilitating combination therapy against multiple GBM-promoting targets. We demonstrate that siRNA delivery with these polymeric nanoparticles is cancer-selective, thereby avoiding potential side effects in healthy cells. We show that we can deliver siRNAs targeting several anti-GBM genes (Robo1, YAP1, NKCC1, EGFR, and survivin) simultaneously and within the same nanoparticles. Robo1 (roundabout homolog 1) siRNA delivery by biodegradable particles was found to trigger GBM cell death, as did non-viral delivery of NKCC1, EGFR, and survivin siRNA. Most importantly, combining several anti-GBM siRNAs into a nanoparticle formulation leads to high GBM cell death, reduces GBM migration in vitro, and reduces tumor burden over time following intratumoral administration. We show that certain genes, like survivin and EGFR, are important for GBM survival, while NKCC1, is more crucial for cancer cell migration. This represents a powerful platform technol. with the potential to serve as a multimodal therapeutic for cancer. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol
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