In 1999,Hayashi, Kazuhiko; Sato, Chisato; Hiki, Shinsuke; Kumagai, Toshio; Tamai, Satoshi; Abe, Takao; Nagao, Yoshimitsu published 《Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1β-methylcarbapenem antibiotic L-084》.Tetrahedron Letters published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:
1-Azabicyclo[1.1.0]butane was successfully synthesized by treatment of 2,3-dibromopropylamine hydrobromide with organolithium compounds and was readily converted to 1-(1,3-thiazolin-2-yl)azetidine-3-thiol hydrochloride and versatile 3-hydroxyazetidine hydrochloride and 3-bromoazetidine hydrobromide. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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