In 2022,Djeujo, Francine Medjiofack; Francesconi, Valeria; Gonella, Maddalena; Ragazzi, Eugenio; Tonelli, Michele; Froldi, Guglielmina published an article in Molecules. The title of the article was 《Anti-α-Glucosidase and Antiglycation Activities of α-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies》.Reference of 3-Aminopropan-1-ol The author mentioned the following in the article:
Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammatory state. This research aims to evaluate the inhibitory activity of α-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on α-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose mols., promoting the postprandial glycemic peak. Antiglycation activity was evaluated using the BSA assay, while antioxidant capacity was detected with the ORAC assay. The inhibition of α-glucosidase activity was studied with multispectroscopic methods along with inhibitory kinetic anal. α-Mangostin and synthetic compounds at 25 μM reduced the production of AGEs, whereas the α-glucosidase activity was inhibited only by the natural compound α-Mangostin decreased enzymic activity in a concentration-dependent manner in the micromolar range by a reversible mixed-type antagonism. CD revealed a rearrangement of the secondary structure of α-glucosidase with an increase in the contents of α-helix and random coils and a decrease in β-sheet and β-turn components. The data highlighted the anti-α-glucosidase activity of α-mangostin together with its protective effects on protein glycation and oxidation damage.3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol) was used in this study.
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Reference of 3-Aminopropan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts