Application In Synthesis of 2-Hydroxyphenylboronic acidIn 2020 ,《Tandem Suzuki Coupling/Intramolecular Oxetane Ring Opening to Form Polycyclic Ring Systems》 was published in Organic Letters. The article was written by DeRatt, Lindsey G.; Lawson, Edward C.; Kumar, Kiran; Hwang, Soyon S.; DesJarlais, Renee L.; Kuduk, Scott D.. The article contains the following contents:
A tandem one-pot reaction featuring a cross-coupling followed by an intramol. oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construction providing diverse multicyclic ring systems with a pendant hydroxymethyl handle for further elaboration. This approach constitutes a convergent method for rapid access to various scaffolds. Furthermore, a comparison of computed low-energy conformers is presented to rationalize instances in which cyclization was not observed In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Application In Synthesis of 2-Hydroxyphenylboronic acid)
2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringApplication In Synthesis of 2-Hydroxyphenylboronic acid
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