《Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance》 was written by Chen, Zhaoming; Wang, Xindong; Liu, Shuai; Li, Yumeng; Zhou, Hao; Guo, Tianying. Computed Properties of C4H11NOThis research focused onzinc dipicolylamine polyethylenimine DNA transfection cyctotoxicity. The article conveys some information:
To investigate the effect of amphiphilic balance of Zn(II)-dipicolylamine analogs on the transfection process, we fabricated a series of Zn(II)-dipicolylamine functional modules (DDAC-Rs) with different hydrophilic-phobic side chains to modify low mol. weight PEI (Zn-DP-Rs) by the Michael addition reaction. Zn-DP-Rs with hydrophilic terminal hydroxy group side chains demonstrate superior overall performance compared to those of hydrophobic alkyl side chains. In terms of the influence of the chain lengths in DDAC-Rs, from Zn-DP-A/OH-3 to Zn-DP-A/OH-5, the corresponding transfection efficiency shows an upward trend as the lengths increase. However, decreasing efficacy is observed with further increase in the length of side chains. In addition, the Zn-DP-Rs with amphiphilic side chains show prominent performance in every respect, highlighting the significance of balance in the amphipathy of side chains in DDAC-Rs. This work is of great significance for the development of polycationic gene carrier materials with excellent performance. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO
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