Application In Synthesis of (R)-Oxiran-2-ylmethanolOn March 19, 2021, Bold, Christian P.; Klaus, Cindy; Pfeiffer, Bernhard; Schurmann, Jasmine; Lombardi, Rafael; Lucena-Agell, Daniel; Diaz, J. Fernando; Altmann, Karl-Heinz published an article in Organic Letters. The article was 《Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide》. The article mentions the following:
Studies are described toward the synthesis of an oxazole-based analog I of (-)-zampanolide. Construction of (-)-dactylolide analog 22 was achieved via alc. II and acid III through esterification and Horner-Wadsworth-Emmons (HWE)-based macrocyclization; however, attempts to attach (Z,E)-sorbamide to I proved unsuccessful. The C(8)-C(9) double bond of the macrocycle was prone to migration into conjugation with the oxazole ring, which may generally limit the usefulness of zampanolide analogs with aromatic moieties as tetrahydropyran replacements. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application In Synthesis of (R)-Oxiran-2-ylmethanol)
(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application In Synthesis of (R)-Oxiran-2-ylmethanol
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