《Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines》 was written by Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan. Application In Synthesis of Azetidin-3-ol hydrochlorideThis research focused ontrifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination. The article conveys some information:
Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Application In Synthesis of Azetidin-3-ol hydrochloride)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application In Synthesis of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts