The author of 《A novel hydroxy-bisphosphonic acid prodrug as a candidate for the delivery of ibuprofen to bone》 were Aoun, Sameh; Bennour, Haythem. And the article was published in Synthetic Communications in 2019. Recommanded Product: 100-83-4 The author mentioned the following in the article:
Active targeting with controlled delivery of anti-inflammatory drugs to the bone is not sufficiently explored. In this study, concise and novel synthesis of a hydroxy-bisphosphonic acid (HBPA) prodrug containing ibuprofen is described. The key step consisted of preparing the HBPA function from a carboxylic acid precursor, in mild conditions and using appropriate Arbuzov reactions with tris(trimethylsilyl)phosphite. This prodrug would be an excellent candidate for the treatment of bone inflammation diseases such as rheumatoid arthritis. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Recommanded Product: 100-83-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts