In 2019,Advanced Functional Materials included an article by Zhang, Yujie; Zhu, Xi; Chen, Xinli; Chen, Qinjun; Zhou, Wenxi; Guo, Qin; Lu, Yifei; Li, Chao; Zhang, Yu; Liang, Donghui; Sun, Tao; Wei, Xunbin; Jiang, Chen. HPLC of Formula: 534-03-2. The article was titled 《Activated Platelets-Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer》. The information in the text is summarized as follows:
The frequent relapse and metastasis characteristics of triple neg. breast cancer (TNBC) make it a fraught issue with very poor prognosis in clinic. An effective treatment for TNBC should prevent and even eliminate metastasis as well as suppress primary lesion expansion. Recent progress reveals that platelets can be recruited and activated by tumor cells through intercellular adhesion mols. (ICAM), and help aggressive circulating tumor cells (CTCs) form metastasis. Therefore, activated platelets are considered with possession of tumor-homing, CTC-capturing, and metastasis-targeting abilities. In this work, a P-selectin (expressed on activated platelet surface) targeting peptide (PSN) is modified on a redox-responsive paclitaxel-loaded micelle (PSN-PEG-SS-PTX4 micelle) to utilize activated platelets as a “”bridge”” for interaction with cancer cells. The PSN-modified micelle can easily adhere to the surface of activated platelets and subsequently capture CTCs in blood circulation. Compared to Taxol and PEG-SS-PTX4 micelle, PSN-PEG-SS-PTX4 micelle also exhibits enhanced primary TNBC/metastasis targeting and penetrating effect through binding with tumor infiltrating platelets and thus significantly improves treatment outcome. More importantly, PSN-PEG-SS-PTX4 micelle potently suppressed lung metastasis of TNBC and reduced incidence of distant liver metastasis. The activated platelet-targeting redox-responsive micelle system provides a promising prospect for the omnidirectional treatment of metastatic cancer. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2) was used in this study.
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 534-03-2
Referemce:
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