Safety of Oxetan-3-olIn 2020 ,《DMSO/t-BuONa/O2-Mediated Aerobic Dehydrogenation of Saturated N-Heterocycles》 appeared in Journal of Organic Chemistry. The author of the article were Yang, Ruchun; Yue, Shusheng; Tan, Wei; Xie, Yongfa; Cai, Hu. The article conveys some information:
Aromatic N-heterocycles such as quinolines I [R1 = H, 8-Cl, 6-OMe, etc.; R2 = H, 3-Me, 4-Ph, etc. X = N; Y = CH2], isoquinolines I [R1 = H; R2 = H, 1-Ph; X = CH2; Y = N] and indoles II [R1 = H, 5-F, 4-Br, etc.; R2 = H, 2-Me; Y = CH2, N] were synthesized via a sodium tert-butoxide promoted oxidative dehydrogenation of the saturated heterocycles in DMSO solution This reaction proceeded under mild reaction conditions with a good functional group tolerance. Mechanistic studies suggested a radical pathway involved hydrogen abstraction of dimsyl radicals from the N-H bond or α-C-H of the substrates, and subsequent oxidation of the nitrogen or α-aminoalkyl radicals. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts