The author of 《Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones》 were Taha, Muhammad; Alkadi, Khaled A. A.; Ismail, Nor Hadiani; Imran, Syahrul; Adam, Aishah; Kashif, Syed Muhammad; Shah, Syed Adnan Ali; Jamil, Waqas; Sidiqqui, Salman; Khan, Khalid Mohammed. And the article was published in Arabian Journal of Chemistry in 2019. SDS of cas: 100-83-4 The author mentioned the following in the article:
A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones I [R1 = C5H4N, 4-FC6H4, 2,4-(HO)2C6H3, etc.] was synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involved a 3-step reaction in which a pyridine diamine was converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target mols. after treating them with the appropriate benzohydrazone derivatives The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound I [R1 = 2,4,6-(HO)3C6H2] (140.16 ± 0.36μM) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4
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