The author of 《Practical synthesis of polysubstituted unsymmetric 1,10-phenanthrolines by palladium catalyzed intramolecular oxidative cross coupling of C(sp2)-H and C(sp3)-H bonds of carboxamides》 were Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin. And the article was published in Organic Chemistry Frontiers in 2019. Recommanded Product: 126456-43-7 The author mentioned the following in the article:
A short sequence for the practical synthesis of polysubstituted unsym. 1,10-phenanthroline compounds was developed based on the palladium-catalyzed oxidative cross coupling reaction of C(sp2)-H/C(sp3)-H bonds of carboxamides. DMAP as a preferred ligand was crucial for the reaction to avoid β-hydride elimination, which may be controlled by the π-π stacking effect between the aryl group of the substrate and DMAP, demonstrated by primary mechanistic studies and X-ray data of the substrate-Pd-DMAP complex. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 126456-43-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts