COA of Formula: C3H9NO2In 2019 ,《Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds》 was published in ACS Applied Bio Materials. The article was written by Sun, Jingjiang; Jung, Dimitri; Schoppa, Timo; Anderski, Juliane; Picker, Marie-Theres; Ren, Yi; Mulac, Dennis; Stein, Nora; Langer, Klaus; Kuckling, Dirk. The article contains the following contents:
Stimuli-responsive self-immolative aliphatic polycarbonates (APCs) and polyesters (APEs) have attractive advantages for biomedical and pharmaceutical applications. In the present work, polycondensation of o-nitrobenzyl-protected serinol was explored as a simple route to obtain light-responsive polycarbonate (LrPC) and polyester (LrPE). By exposure to UV light, these polymers decomposed rapidly and completely into oligomers and small mols., as detected by size exclusion chromatog. (SEC), UV/vis, and 1H NMR spectroscopies. The degradation mechanism of serinol-based APC and APE was investigated with the help of the Boc-protected model APC and APE, showing that the APC underwent intramol. cyclization, accompanied by intermol. transcarbamation, and degraded into oxazolidinone and 2-aminopropanol terminated oligourethanes. Different from APC, the degradation process of serinol-based APE has been proven by electrospray ionization time-of-flight mass spectrometry (ESI-ToF-MS) to follow intramol. cyclization of the functional amine group with the remote ester group, forming a ten-membered cyclic degradation compound Further processing of the serinol-based polymers was performed by preparation of nanoparticles (NP). With light-responsive characteristics, a drug delivery system could be potentially obtained enabling a controllable drug release. Based on this strategy, a variety of self-immolative polymers responsive to different triggers can be prepared by polycondensation without the limit of ring-opening polymerization and will expand the family of biodegradable polymers. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO2
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