Application of 1082066-29-2On October 31, 2019 ,《Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer》 appeared in Bioorganic Chemistry. The author of the article were Skarbek, Charles; Serra, Silvia; Maslah, Hichem; Rascol, Estelle; Labruere, Raphael. The article conveys some information:
This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of doxorubicin and their biol. evaluation as anticancer agents. The determination of the most sensitive cancer type toward arylboronate prodrugs is crucial for further consideration of these mols. in clin. phase. To address this goal, an arylboronate-based profluorescent probe was used to compare the capacity of various cancer cell lines to efficiently convert the precursor into the free fluorophore. On the selected MiaPaCa-2 pancreatic cancer cells, a benzeneboronate prodrug exhibited 67% of the cytotoxicity obtained with the free doxorubicin. The prodrug was also able to induce tumor regression on MiaPaCa-2 pancreatic tumor model in ovo. Using this model, the amount of free doxorubicin liberated from this prodrug into the tumor was equivalent to the quantity measured after direct intratumoral injection of the same concentration of doxorubicin. After reading the article, we found that the author used (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Application of 1082066-29-2)
(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application of 1082066-29-2
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