In 2019,Biomedicine & Pharmacotherapy included an article by Pham, Lyna; Dang, Le Hang; Truong, Minh Dung; Nguyen, Thi Hiep; Le, Ly; Le, Van Thu; Nam, Nguyen Dang; Bach, Long Giang; Nguyen, Van Toan; Tran, Ngoc Quyen. Formula: C3H9NO. The article was titled 《A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application》. The information in the text is summarized as follows:
This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheol. study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel-sol-gel transition following the function of temperature Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier’s function of damaged skin such as wound or skin cancer. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)
3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Formula: C3H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts