The author of 《Folate-conjugated chitosan-pluronic P123 nanogels: synthesis and characterizations towards dual drug delivery》 were Nguyen, Van Toan; Nguyen, Thi Huong; Dang, Le Hang; Vu-Quang, Hieu; Tran, Ngoc Quyen. And the article was published in Journal of Nanomaterials in 2019. Reference of 4-Aminobutan-1-ol The author mentioned the following in the article:
In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27 ± 2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate pos. potential value (39.43 ± 3.45 mV) and the lower critical micelle concentration (0.036 mg/mL). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63 ± 0.42 of PTX and 97.82 ± 0.48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74 ± 0.23 nM which was higher than that of CP-FA/PTX (IC50 = 8.20 ± 1.41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol
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