Category: alcohols-buliding-blocksIn 2022 ,《Crosslinked Protein Delivery Strategy with Precise Activity Regulation Properties for Cancer Therapy and Gene Editing》 appeared in Advanced Healthcare Materials. The author of the article were Liu, Ning; Zhu, Lianghan; Sun, Honghao; Zhou, Zhanwei; Dong, Jingwen; Sun, Minjie. The article conveys some information:
Protein drugs hold tremendous promise for therapeutic applications due to their direct and superior pharmacol. effects. However, protein drugs can be degraded in blood stream and unable to cross many phys. barriers to exert therapeutic effect. Degradable synthetic crosslinking is a versatile strategy to enhance the stability of the nanoparticle in a complex physiol. medium and is helpful to get through phys. barriers. Herein, crosslinked polypeptide (PABP) composed of poly-amino acids including cystine, tyrosine, lysine, ketal bridge, and polyethylene glycol (PEG) is modularly explored and synthesized for protein delivery. Notably, plasma membrane V-ATPase is the particular pathway which induces the macropinocytosis of the inner peptide analogous core (PAB/protein) after the outer PEG shell disassocn. at tumor intercellular sites. In addition, PABP/protein achieves proteins′ activity shielding in systemic circulation and recovery in tumor cytoplasm precisely. In application, PABP/RNase-A shows satisfying tumor accumulation and antineoplastic efficacy. More importantly, PABP/Cas9 + small guide RNA displays obvious gene editing efficiency. The crosslinked protein delivery strategy not only makes the accurate protein transport and activity regulation possible but also is promising in paving the way for clin. translation of protein drugs. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts