Lee, Cayo; Lai, Joey; Epifanov, Maxim; Wang, Cindy Xinyun; Sammis, Glenn M. published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Efficient protocol for the SO2F2-mediated deoxyfluorination of aliphatic alcohols》.Product Details of 13325-10-5 The article contains the following contents:
Herein the sulfuryl fluoride-mediated deoxyfluorination of alcs. using room temperature reaction conditions in only an hour is reported. A wide range of primary aliphatic alcs. were efficiently converted to the corresponding fluoride in 46-70% isolated yields. Secondary alcs. were also effectively deoxyfluorinated in 50-92% yields. Chiral secondary alcs. were cleanly converted to the corresponding alkyl fluoride with only a minor deterioration of the enantioenrichment. A steroid derivative also underwent deoxyfluorination in 50% yield and 5.9:1 dr, with the major product resulting from net inversion of the stereocenter.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts