In 2019,Medicinal Chemistry Research included an article by Khan, Ayesha; Khan, Ajmal; Farooq, Umar; Taha, Muhammad; Shah, Syed Adnan Ali; Halim, Sobia Ahsan; Akram, Arfa; Khan, Mohammed Ziauddin; Jan, Abdul Khaliq; Al-Harrasi, Ahmed. Quality Control of 3,5-Dihydroxybenzaldehyde. The article was titled 《Oxindole-based chalcones: synthesis and their activity against glycation of proteins》. The information in the text is summarized as follows:
Diabetes mellitus, a metabolic disorder, is characterized by a substantial hyperglycemia. Prevalence of hyperglycemia for longer period of time can cause nonenzymic condensation of sugar in blood with amino group of protein and give rise to advanced glycation end products (AGEs). AGEs play a major role in the onset of late diabetic complications including diabetic retinopathy, nephropathy, neuropathy and cardiovascular diseases. There is a need to establish potential therapeutic regimens that can effectively inhibit the formation of AGEs. To this end a series of novel oxindole-based chalcones have been investigated for their antiglycation potential. Analogs 1 (IC50 = 155.22 ± 2.98 μM), 3 (IC50 = 195.95 ± 0.43 μM), 4 (IC50 = 289.47 ± 2.47 μM), 5 (IC50 = 222.44 ± 4.03 μM), 7 (IC50 = 251.27 ± 2.80 μM), and 20 (224.23 ± 1.93 μM) showed potent inhibitory activity against glycation compared to the reference Rutin (IC50 = 294.5 ± 1.5 μM). These results reveal that multiple hydroxyl substituents and their position on the aromatic ring play a key role in inhibitory effect due to their hydrogen bonding potential. The study also reveals the influence of substituents on the binding capabilities and in turn inhibitory potential of different analogs.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Quality Control of 3,5-Dihydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts