Recommanded Product: Oxetan-3-olIn 2021 ,《Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues》 appeared in Nature Communications. The author of the article were Kastan, Nathaniel; Gnedeva, Ksenia; Alisch, Theresa; Petelski, Aleksandra A.; Huggins, David J.; Chiaravalli, Jeanne; Aharanov, Alla; Shakked, Avraham; Tzahor, Eldad; Nagiel, Aaron; Segil, Neil; Hudspeth, A. J.. The article conveys some information:
Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling. The substance prevents Yap phosphorylation and induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Muller glia in retinal organoids. The RNA sequencing indicates that the inhibitor reversibly activates the expression of transcriptional Yap targets: upon withdrawal, a subset of supporting-cell progeny exits the cell cycle and upregulates genes characteristic of sensory hair cells. Our results suggest that the pharmacol. inhibition of Lats kinases may promote initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the adult mammalian inner ear. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)
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