In 2022,Iqbal, Sajid; Martins, Alessandro F.; Sohail, Muhammad; Zhao, Jingjing; Deng, Qi; Li, Muhan; Zhao, Zhongxi published an article in Frontiers in Pharmacology. The title of the article was 《Synthesis and characterization of poly (β-amino Ester) and applied PEGylated and non-PEGylated poly (β-amino ester)/plasmid DNA nanoparticles for efficient gene delivery》.Quality Control of 4-Aminobutan-1-ol The author mentioned the following in the article:
Polymer-based nanocarriers require extensive knowledge of their chemistries to learn functionalization strategies and understand the nature of interactions that they establish with biol. entities. In this research, the poly (ss-amino ester) (PβAE-447) was synthesized and characterized, aimed to identify the influence of some key parameters in the formulation process. Initially; PβAE-447 was characterized for aqueous solubility, swelling capacity, proton buffering ability, and cytotoxicity study before nanoparticles formulation. Interestingly, the polymer-supported higher cell viability than the Polyethylenimine (PEI) at 100 μg/mL. PβAE-447 complexed with GFP encoded plasmid DNA (pGFP) generated nanocarriers of 184 nm hydrodynamic radius (+7.42 mV Zeta potential) for cell transfection. Transfection assays performed with PEGylated and lyophilized PβAE-447/pDNA complexes on HEK-293, BEAS-2B, and A549 cell lines showed better transfection than PEI. The outcomes toward A549 cells (above 66%) showed the highest transfection efficiency compared to the other cell lines. Altogether, these results suggested that characterizing physicochem. properties pave the way to design a new generation of PβAE-447 for gene delivery. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol
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