COA of Formula: C3H8ClNOIn 2012 ,《Synthesis of the side chain of tebipenem pivoxil》 was published in Zhongguo Xinyao Zazhi. The article was written by Huang, Xiaoguang; Huang, Binge; Zhu, Shaoxuan. The article contains the following contents:
The side chain 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride of tebipenem pivoxil was synthesized. 1-(4,5-Dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride was prepared from 2-(methylthio)-4,5-dihydrothiazole by a 4-step process, i.e. successively reacted with 3-hydroxyazetidine hydrochloride, methanesulfonyl chloride, potassium ethanethioate and hydrolysis. The total yield of 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride was 42%. This method increases the yield of 1-(4,5-dihydrothiazol-2-yl) azetidine-3-thiol hydrochloride, simplifies the process and decreases the cost. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6COA of Formula: C3H8ClNO)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.COA of Formula: C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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