In 2022,Hong, Xianfang; Guo, Jingcheng; Liu, Jinhua; Cao, Wei; Wei, Chenlong; Zhang, Ye; Zhang, Xiaoxiang; Fu, Zhenqian published an article in Science China: Chemistry. The title of the article was 《Organocatalytic dynamic kinetic resolution of N-arylindole lactams: Atroposelective construction of axially chiral amino acids bearing a C-N chiral axis》.HPLC of Formula: 100-55-0 The author mentioned the following in the article:
Organocatalytic dynamic kinetic resolution of configurationally labile cyclic mols. represents one of the most efficient methods for the atroposelective construction of axially chiral mols. bearing a tetra-ortho-substituted chiral axis. Notably, this privileged strategy is limited to constructing a C-C chiral axis. Herin, organocatalytic dynamic kinetic resolution of configurationally labile N-arylindole lactams has been successfully achieved for the first time, allowing for access to a structurally diverse set of axially chiral N-arylindole amino esters with a tetra-ortho-substituted C-N chiral axis in excellent yields and atroposelectivities. In addition to the N-arylindole skeleton, N-aryl thieno[3,2-b]pyrrole, furo[3,2-b]pyrrole, and pyrrolo[2,3-b]pyridine skeletons are also compatible with this transformation. This transition-metal-free facile strategy features a broad substrate scope, mild reaction conditions, easy scale-up and excellent atom economy. Several potentially valuable mols., such as axially chiral peptides, were efficiently generated from the resulting configurationally stable axially-chiral N-arylindole amino esters, demonstrating the power of this strategy. In the part of experimental materials, we found many familiar compounds, such as 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-55-0
Referemce:
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Alcohols – Chemistry LibreTexts