Safety of 3-(4-Pyridyl)-2-propyn-1-olOn March 7, 2005, Feuerstein, Marie; Doucet, Henri; Santelli, Maurice published an article in Tetrahedron Letters. The article was 《Sonogashira cross-coupling reactions with heteroaryl halides in the presence of a tetraphosphine-palladium catalyst》. The article mentions the following:
Heteroaryl halides undergoes cross-couplings with alkynes in good yields in the presence of [PdCl(C3H5)]2/cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as catalyst. A variety of heteroaryl halides such as pyridines, quinolines, a pyrimidine, an indole, a thiophene, or a thiazole were used successfully. The reaction also tolerates several alkynes such as phenylacetylene and a range of alk-1-ynols. Furthermore, this catalyst can be used at low loading with some substrates. In addition to this study using 3-(4-Pyridyl)-2-propyn-1-ol, there are many other studies that have used 3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9Safety of 3-(4-Pyridyl)-2-propyn-1-ol) was used in this study.
3-(4-Pyridyl)-2-propyn-1-ol(cas: 93524-95-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-(4-Pyridyl)-2-propyn-1-ol
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