Fergus, Claire; Al-qasem, Mashael; Cotter, Michelle; McDonnell, Ciara M.; Sorrentino, Emiliano; Chevot, Franciane; Hokamp, Karsten; Senge, Mathias O.; Southern, John M.; Connon, Stephen J.; Kelly, Vincent P. published an article in 2021. The article was titled 《The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity》, and you may find the article in Nucleic Acids Research.Synthetic Route of C9H11NO The information in the text is summarized as follows:
Base-modification can occur throughout a tRNA mol.; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. Previously, we demonstrated that the queuosine modification at position 34 can be substituted with an artificial analog via the queuine tRNA ribosyltransferase enzyme to induce disease recovery in an animal model of multiple sclerosis. Here, we demonstrate that the human enzyme can recognize a very broad range of artificial 7-deazaguanine derivatives for tRNA incorporation. By contrast, the enzyme displays strict specificity for tRNA species decoding the dual synonymous NAU/C codons, determined using a novel enzyme-RNA capture-release method. Our data highlight the broad scope and therapeutic potential of exploiting the queuosine incorporation pathway to intentionally engineer chem. diversity into the tRNA anticodon. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Synthetic Route of C9H11NO)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C9H11NO
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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts