Cubane, bicyclo[1.1.1]pentane and bicyclo[2.2.2]octane: Impact and thermal sensitiveness of carboxyl-, hydroxymethyl- and iodo-substituents was written by Dallaston, Madeleine A.; Houston, Sevan D.; Williams, Craig M.. And the article was included in Chemistry – A European Journal on September 21,2020.Recommanded Product: Cubane-1,4-diyldimethanol The following contents are mentioned in the article:
With the burgeoning interest in cage motifs for bioactive mol. discovery, and the recent disclosure of 1,4-cubane-dicarboxylic acid impact sensitivity, more research into the safety profiles of cage scaffolds is required. Therefore, the impact sensitivity and thermal decomposition behavior of judiciously selected starting materials and synthetic intermediates of cubane, bicyclo[1.1.1]pentane (BCP), and bicyclo[2.2.2]octane (BCO) were evaluated via hammer test and sealed cell differential scanning calorimetry, resp. Iodo-substituted systems were found to be more impact sensitive, whereas hydroxymethyl substitution led to more rapid thermo-decomposition Cubane was more likely to be impact sensitive with these substituents, followed by BCP, whereas all BCOs were unresponsive. The majority of derivatives were placed substantially above Yoshida thresholds-a computational indicator of sensitivity. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Recommanded Product: Cubane-1,4-diyldimethanol).
Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: Cubane-1,4-diyldimethanol
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