Cadena-Cruz, Jose Eduardo; Guaman-Ortiz, Luis M.; Romero-Benavides, Juan Carlos; Bailon-Moscoso, Natalia; Murillo-Sotomayor, Kevin E.; Ortiz-Guaman, Nadia V.; Heredia-Moya, Jorge published their research in BMC Chemistry in 2021. The article was titled 《Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities》.SDS of cas: 100-83-4 The article contains the following contents:
The 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I (R = Ph, 3,4-dihydroxyphenyl, 2-nitrophenyl, etc.) were synthesized by a three-component reaction of 3-methyl-1-phenyl-5-pyrazolone with various benzaldehydes RCHO catalyzed by sodium acetate at room temperature The structures of all synthesized compounds were characterized by physicochem. properties and spectral means (IR and NMR) and evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives I were synthesized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound I (R = 3,4-dihydroxyphenyl) proved to be a very potent scavenger with an IC50 of 6.2 ± 0.6μM and exhibited an IC50 of 9.9 ± 1.1μM against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4
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