Related Products of 27489-62-9In 2018 ,《α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes》 was published in Inorganic Chemistry. The article was written by Biancalana, Lorenzo; Batchelor, Lucinda K.; Funaioli, Tiziana; Zacchini, Stefano; Bortoluzzi, Marco; Pampaloni, Guido; Dyson, Paul J.; Marchetti, Fabio. The article contains the following contents:
Ruthenium half-sandwich η6-p-cymene cationic diimine complexes [(η6-cymene)RuCl(RN:CHCHNR)][NO3] (R = Cy, 4-HOC6H10, 4-HOC6H4, 2-MeCO2C6H4OCOC6H4, 4-C7H15OCOC6H4) were prepared and examined for cytotoxicity and antitumor activity. α-Diimines are among the most robust and versatile ligands available in synthetic coordination chem., possessing finely tunable steric and electronic properties. A series of novel cationic ruthenium(II) p-cymene complexes bearing simple α-diimine ligands, [(η6-p-cymene)RuCl{κ2N-(HCNR)2}]NO3 (1-3; R = Cy, 4-C6H10OH, 4-C6H4OH), were prepared in near-quant. yields as their nitrate salts. [2]NO3 displays high water solubility The potential of the α-diimine ligand in [3]NO3 as a carrier of bioactive mols. was investigated via esterification reactions with the hydroxyl groups. Thus, the double-functionalized derivatives [(η6-p-cymene)RuCl{κ2N-(HCN(4-C6H4OCO-R))2}]NO3 (4, 5, 6; R = Me, 2-MeCO2C6H4, 4-C7H15) were obtained in good-to-high yields. UV-vis and multinuclear NMR spectroscopy and cyclic voltammetric studies in aqueous solution revealed only minor ruthenium chloride hydrolytic cleavage, biol. accessible reduction potentials, and pH-dependent behavior of [3]NO3. D. functional theory anal. was performed in order to compare the Ru-Cl bond strength in [1]+ with the analogous ethylenediamine complex, showing that the higher stability observed in the former is related to the electron-withdrawing properties of the α-diimine ligand. In vitro cytotoxicity studies were performed against tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK-293) cell lines, with the complexes bearing simple α-diimine ligands ranging from inactive to IC50 values in the low micromolar range. The complexes functionalized with bioactive components, i.e., [5]NO3 and [6]NO3, exhibited a marked increase in the cytotoxicity with respect to the precursor [3]NO3.trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9) was used in this study.
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Related Products of 27489-62-9
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