Quality Control of 3-HydroxybenzaldehydeIn 2022 ,《Design, Synthesis, and Biological Screening for Cytotoxic Activity of Monastrol Analogues》 was published in Polycyclic Aromatic Compounds. The article was written by Asham, Hila; Bohlooli, Shahab; Dostkamel, Donya; Rezvanpoor, Sadaf; Sepehri, Saghi. The article contains the following contents:
A series of 1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives I (Ar = 3-HOC6H4, 4-O2NC6H4, 4-BrC6H5; X = O, S; R = CH3, C2H5) was synthesized through one-pot condensation reaction. Then, they were investigated for in vitro cytotoxic activity. These derivatives showed a good cytotoxic activity against three human cancer cell lines counting MCF-7, HepG-2, and AGS. Among these derivatives, mols. I (Ar = 4-BrC6H5; X = S; R = C2H5) and I (Ar = 3-HOC6H5; X = S; R = CH3) exhibited the highest activity against all cell lines. In vitro cytotoxicity evaluation on all mols. showed that sulfur atom at C2 position, length chain of ester moiety and different substituents on Ph ring positions of tetrahydropyrimidine influenced the antiproliferative activity. Furthermore, according to docking studies a good correlation between exptl. activity and binding affinity was observed In silico studies of mols. showed the participation of hydrophobic interactions and hydrogen bonds with allosteric site Eg5 active site similar to monastrol, Eg5 inhibitor, and co-crystal ligand. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Quality Control of 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Quality Control of 3-Hydroxybenzaldehyde
Referemce:
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