On May 31, 2015, Zhao, Yanfang; Xu, Lubin published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Chiral Separation of D,L-p-Hydroxyphenylglycine by Ligand Exchange Micellar Electrokinetic Capillary Chromatography. And the article contained the following:
D-P-Hydroxyphenylglycine (D-p-HPG) is an important intermediate for the synthesis of semi-synthetic antibiotics. Owing to the importance of optical purity of D-p-HPG, it is necessary to be able to chirally sep. D,L-p-HPG and monitor the enantiomeric purity of D-p-HPG in the pharmaceutical industry. A Cu(II) complex with L-valine (L-Val) was used as a chiral selector for ligand exchange chiral separation of D,L-p-HPG by micelle electrokinetic capillary chromatog. Optical resolution of D,L-p-HPG was obtained with a running buffer of 20 mM NH4OAc, 40 mM sodium dodecylsulfate (SDS), 10 mM Cu(II) and 20 mM L-Val at pH 8.5 in <10 min. The enantiomer migration order was L-p-HPG before D-p-HPG, which was most suitable for the determination of minor L-p-HPG in the presence of a large excess of D-p-HPG. Separation parameters such as pH, SDS concentration, the molar ratio of Cu(II) to L-Val, the concentration of the chiral metal complex, and capillary temperature were studied. The present method can also be used for assaying the enantiomeric excess of D-p-HPG. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH
The Article related to hydroxyphenylglycine enantioseparation ligand exchange micellar electrokinetic capillary chromatog, Organic Analytical Chemistry: Separations and other aspects.Recommanded Product: H-Phg(4-OH)-OH
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