On March 1, 2006, Sakya, Subas M.; Cheng, Hengmiao; Lundy DeMello, Kristin M.; Shavnya, Andrei; Minich, Martha L.; Rast, Bryson; Dutra, Jason; Li, Chao; Rafka, Robert J.; Koss, David A.; Li, Jin; Jaynes, Burton H.; Ziegler, Carl B.; Mann, Donald W.; Petras, Carol F.; Seibel, Scott B.; Silvia, Annette M.; George, David M.; Hickman, Anne; Haven, Michelle L.; Lynch, Michael P. published an article.Recommanded Product: 72364-46-6 The title of the article was 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. And the article contained the following:
Structure-activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine COX enzymes are described. The 4-cyano-5-alkyl ethers were found to have excellent potency and selectivity, whereas the 5-thioethers were potent but less selective than the ether analogs in a canine whole blood (CWB) COX-2 assay. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Recommanded Product: 72364-46-6
The Article related to canine cox2 inhibitor heterocyclic pyrazole preparation sar, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 72364-46-6
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